AMG-Tie2-1
AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM[1].
Product Specifications
CAS Number
[870223-96-4]
UNSPSC
12352005
Target
VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amg-tie2-1.html
Purity
99.5
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
CNC1=NC(C2=CC=CN=C2OC3=C(C)C=CC(C(NC4=CC=CC(C(F)(F)F)=C4)=O)=C3)=CC=N1
Molecular Formula
C25H20F3N5O2
Molecular Weight
479.45
References & Citations
[1]Brian L Hodous, et al. Evolution of a highly selective and potent 2- (pyridin-2-yl) -1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50 (4) :611-26.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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