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AMG-Tie2-1

Product Specifications

UNSPSC Description

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM[1].

Target Antigen

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amg-tie2-1.html

Purity

99.5

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

CNC1=NC(C2=CC=CN=C2OC3=C(C)C=CC(C(NC4=CC=CC(C(F)(F)F)=C4)=O)=C3)=CC=N1

Molecular Weight

479.45

References & Citations

[1]Brian L Hodous, et al. Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50(4):611-26.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-13023/AMG-Tie2-1-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-13023/AMG-Tie2-1-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

870223-96-4

Available Sizes

Curated Selection

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