AMG-Tie2-1

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM[1].

Product Specifications

CAS Number

[870223-96-4]

UNSPSC

12352005

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amg-tie2-1.html

Purity

99.5

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

CNC1=NC(C2=CC=CN=C2OC3=C(C)C=CC(C(NC4=CC=CC(C(F)(F)F)=C4)=O)=C3)=CC=N1

Molecular Formula

C25H20F3N5O2

Molecular Weight

479.45

References & Citations

[1]Brian L Hodous, et al. Evolution of a highly selective and potent 2- (pyridin-2-yl) -1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50 (4) :611-26.