NS1643

NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells[1][2].

Product Specifications

CAS Number

[448895-37-2]

UNSPSC

12352005

Hazard Statement

H301, H319

Target

Autophagy; Potassium Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NS1643.html

Purity

99.04

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=C(O)C=CC(C(F)(F)F)=C1)NC2=C(O)C=CC(C(F)(F)F)=C2

Molecular Formula

C15H10F6N2O3

Molecular Weight

380.24

Precautions

H301, H319

References & Citations

[1]Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69 (2) :658-65. Epub 2005 Nov 11.|[2]Breuer EK, et al. Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling. Cell Death Dis. 2019 Feb 21;10 (3) :180.