Methocarbamol

Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research[1][2][3].

Product Specifications

CAS Number

[532-03-6]

UNSPSC

12352005

Hazard Statement

H302, H317, H334

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Methocarbamol.html

Concentration

10mM

Purity

99.80

Solubility

DMSO : ≥ 100 mg/mL|H2O : 4 mg/mL (ultrasonic)

Smiles

OC(COC1=CC=CC=C1OC)COC(N)=O

Molecular Formula

C11H15NO5

Molecular Weight

241.24

Precautions

H302, H317, H334

References & Citations

[1]Bruce, R.B., L.B. Turnbull, and J.H. Newman, Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci, 1971. 60 (1) : p. 104-6.|[2]Sica, D.A., et al., Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol, 1990. 39 (2) : p. 193-4.|[3]Yaxin Zhang, et al. Methocarbamol blocks muscular Na v 1.4 channels and decreases isometric force of mouse muscles. Muscle Nerve. 2020 Oct 11.