17-HDHA

17-HDHA is a DHA-derived specialized proresolving mediator (SPM) . 17-HDHA enhances the antibody-mediated immune response against influenza virus. 17-HDHA enhances the differentiation of B cells toward the CD27+ CD38+ antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells[1][2].

Product Specifications

CAS Number

[90780-52-2]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/17-hdha.html

Concentration

290.28 μM * 500 μL in Ethanol

Purity

98.8

Solubility

10 mM in DMSO

Smiles

CC/C=C\CC(O)/C=C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O

Molecular Formula

C22H32O3

Molecular Weight

344.49

Precautions

H225, H319

References & Citations

[1]Ramon S, et al. The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? J Immunol. 2014 Dec 15;193 (12) :6031-40.|[2]Ramon S, et al. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J Immunol. 2012 Jul 15;189 (2) :1036-42.