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Stiripentol

Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59±0.07 and 0.516±0.065 μM and IC50 of 1.58 and 3.29 μM, respectively.

Product Specifications

Product Name Alternative

BCX2600

UNSPSC

12352005

Hazard Statement

H302

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Stiripentol.html

Purity

99.99

Solubility

DMSO : 150 mg/mL (ultrasonic; warming)

Smiles

CC(C)(C)C(O)/C=C/C1=CC=C(OCO2)C2=C1

Molecular Formula

C14H18O3

Molecular Weight

234.29

Precautions

H302

References & Citations

[1]Giraud C, et al. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.Drug Metab Dispos. 2006 Apr;34 (4) :608-11. Epub 2006 Jan 13.|[2]Cao D, et al. Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome. Epilepsia. 2012 Jul;53 (7) :1140-5.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-103392/Stiripentol-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-103392/Stiripentol-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

CYP2; CYP3

CAS Number

[49763-96-4]

Available Sizes

Curated Selection

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