Muscarinic Toxin 7

<strong>Muscarinic Toxin 7</strong> <strong>Catalog number:</strong> MDP0711 <strong>CAS Number: </strong>370570-43-7 <strong>Sequence: </strong>Leu-Thr-Cys-Val-Lys-Ser-Asn-Ser-Ile-Trp-Phe-Pro-Thr-Ser-Glu-Asp-Cys-Pro-Asp-Gly-Gln-Asn-Leu-Cys-Phe-Lys-Arg-Trp-Gln-Tyr-Ile-Ser-Pro-Arg-Met-Tyr-Asp-Phe-Thr-Arg-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Lys-Ala-Glu-Tyr-Arg-Asp-Val-Ile-Asn-Cys-Cys-Gly-Thr-Asp-Lys-Cys-Asn-Lys (Disulfide bonds between Cys3-Cys24, Cys17-Cys42, Cys46-Cys57, and Cys58-Cys63) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 7472.4 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Saleh A, Sabbir MG, Aghanoori MR, Smith DR, Roy Chowdhury SK, Tessler L, Brown J, Gedarevich E, Kassahun MZ, Frizzi K, Calcutt NA, Fernyhough P. Muscarinic Toxin 7 Signals Via Ca(2+)/Calmodulin-Dependent Protein Kinase Kinase β to Augment Mitochondrial Function and Prevent Neurodegeneration Mol Neurobiol. 2020 Jun;57(6):2521-2538. 2: Xu J, Zhao H, Zheng Z, Wang Y, Niu Y, Wang H, Xu J, Lu Y, Chen H. Structural determinants for the interactions between muscarinic toxin 7 and muscarinic acetylcholine receptors J Mol Recognit. 2015 Apr;28(4):239-52. 3: Kukkonen A, Peräkylä M, Akerman KE, Näsman J. Muscarinic toxin 7 selectivity is dictated by extracellular receptor loops J Biol Chem. 2004 Dec 3;279(49):50923-9. 4: Olianas MC, Maullu C, Adem A, Mulugeta E, Karlsson E, Onali P. Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7) Br J Pharmacol. 2000 Oct;131(3):447-52. 5: Rondinelli S, Näreoja K, Näsman J. Molecular conversion of muscarinic acetylcholine receptor M(5) to muscarinic toxin 7 (MT7)-binding protein Toxins (Basel). 2011 Nov;3(11):1393-404. 6: Fruchart-Gaillard C, Mourier G, Marquer C, Ménez A, Servent D. Identification of various allosteric interaction sites on M1 muscarinic receptor using 125I-Met35-oxidized muscarinic toxin 7 Mol Pharmacol. 2006 May;69(5):1641-51. 7: Marquer C, Fruchart-Gaillard C, Mourier G, Grandjean O, Girard E, le Maire M, Brown S, Servent D. Influence of MT7 toxin on the oligomerization state of the M1 muscarinic receptor Biol Cell. 2010 Apr 9;102(7):409-20. 8: Fruchart-Gaillard C, Mourier G, Marquer C, Stura E, Birdsall NJ, Servent D. Different interactions between MT7 toxin and the human muscarinic M1 receptor in its free and N-methylscopolamine-occupied states Mol Pharmacol. 2008 Dec;74(6):1554-63. 9: Wirtshafter D. The selective m1 muscarinic antagonist MT-7 blocks pilocarpine-induced striatal Fos expression Brain Res. 2006 Apr 26;1085(1):127-31. <a href="https://pubmed.ncbi.nlm.nih.gov/21679501">10: Lung MA. M1 and M3 muscarinic receptors mediate relaxation and contraction in canine nasal veins Am J Rhinol Allergy. 2011 Mar-Apr;25(2):e60-5. </a> <br><strong>Products Related to Muscarinic Toxin 7 can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>