γ1-MSH

γ1-MSH is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor. γ1-MSH displays ~40-fold selectivity over MC4 (Ki=1318 nM) [1].

Product Specifications

CAS Number

[72629-65-3]

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/γ1-msh.html

Purity

99.60

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@H](N)C(N[C@@H](C(C)C)C(N[C@@H](CCSC)C(NCC(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C72H97N21O14S

Molecular Weight

1512.74

References & Citations

[1]Lindblom J, et al. Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 1998;810 (1-2) :161-171. doi:10.1016/s0006-8993 (98) 00918-4