Ipivivint
Ipivivint (Compound 38) is an orally active and potent CDC-like kinase (CLK) inhibitor with EC50 of 1 nM and 7 nM for CLK2 (human) and CLK3 (human), respectively. Ipivivint also inhibits the Wnt pathway (EC50=13 nM) and tyrosine phosphorylation-regulated kinase 1A (human) (EC50=5 nM) [1][2].
Product Specifications
CAS Number
[1481617-15-5]
UNSPSC
12352005
Target
CDK; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ipivivint.html
Purity
99.95
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CN(C)CC1=CC(C2=CN=C(NN=C3C(N4)=NC5=C4C(C6=CC(F)=CC=C6)=CN=C5)C3=C2)=CN=C1
Molecular Formula
C26H21FN8
Molecular Weight
464.50
References & Citations
[1]Betty Tam, et al. Methods of treating cancer using a clk inhibitor. WO2020006115A1.|[2]Ipivivint bioassay results. PubChem.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CDK2; CDK3
Available Sizes
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