PROTAC SMARCA2/4-degrader-31
PROTAC SMARCA2/4-degrader-31 (Compound I-280) is a degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-31 degrades SMARCA2 in A549 with DC50 SMARCA4 in MV411 with DC50 [1].
Product Specifications
CAS Number
[2568273-83-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-4-degrader-31.html
Smiles
OC1=CC=CC=C1C2=CC(N3CC(N4C5=NC(C6CCN([C@H]7CC[C@H](C8=CC(N(C)C(N9C%10CCC(NC%10=O)=O)=O)=C9C=C8)CC7)CC6)=NC=C5)CCC4C3)=C(N)N=N2
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
References & Citations
[1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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