4-PQBH
4-PQBH is a potent Nur77 binder (KD=1.17 μM) . 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research[1].
Product Specifications
CAS Number
[2243355-51-1]
Product Name Alternative
CNS 1102 (free base)
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A; Paraptosis
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-pqbh.html
Concentration
10mM
Purity
99.14
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(N/N=C/C1=CC=NC=C1)C2=CC=C(NC3=CC=NC4=CC=CC=C34)C=C2
Molecular Formula
C22H17N5O
Molecular Weight
367.40
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1
Available Sizes
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