Sweroside

Sweroside is an iridoid glycoside that targets multiple targets, including the Keap1/Nrf2 axis, NLRP3 inflammasome, SIRT1, NF-κB, AMPK/mTOR pathway, and caspase family. Sweroside promotes Nrf2 nuclear translocation by competitively binding to Keap1. Sweroside also inhibits oxidative stress and NLRP3-mediated pyroptosis by activating Nrf2, inhibits NF-κB inflammatory pathway by activating SIRT1, and promotes autophagy and induces caspase-dependent apoptosis via the AMPK/mTOR pathway. Sweroside has antioxidant, anti-inflammatory, anti-apoptotic, and lipid metabolism regulating activities, and can be used in the research of myocardial ischemia-reperfusion injury, leukemia, acute lung injury, non-alcoholic fatty liver disease, and other fields[1][2][3][4].

Product Specifications

CAS Number

[14215-86-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Apoptosis; Autophagy; Keap1-Nrf2; NF-κB; NOD-like Receptor (NLR) ; PARP; Pyroptosis; Sirtuin

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sweroside.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

C=C[C@@H]1[C@@](CCOC2=O)([H])C2=CO[C@H]1O[C@]([C@@H]([C@@H](O)[C@@H]3O)O)([H])O[C@@H]3CO

Molecular Formula

C16H22O9

Molecular Weight

358.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Li J, et al. Sweroside Protects Against Myocardial Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Pyroptosis Partially via Modulation of the Keap1/Nrf2 Axis. Front Cardiovasc Med. 2021 Mar 19;8:650368.|[2]Han XL, et al. Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis. Biomed Pharmacother. 2017 Nov;95:477-486.|[3]Wang J, et al. Anti-inflammatory Effects of Sweroside on LPS-Induced ALI in Mice Via Activating SIRT1. Inflammation. 2021 Oct;44 (5) :1961-1968.|[4]Ding Y, et al. Sweroside alleviates hepatic steatosis in part by activating AMPK/mTOR-mediated autophagy in mice. J Cell Biochem. 2023 Jul;124 (7) :1012-1022.