AZD1283

AZD1283 is a potent P2Y12 receptor antagonist with a binding IC50 of 11 nM and a GTPγS IC50 of 25 nM. AZD1283 has excellent antiplatelet aggregation potency. AZD1283 can be used to research thromboembolic disorders[1][2].

Product Specifications

CAS Number

[919351-41-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/AZD1283.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(C(OCC)=O)C=C(C#N)C(N2CCC(C(NS(=O)(CC3=CC=CC=C3)=O)=O)CC2)=N1

Molecular Formula

C23H26N4O5S

Molecular Weight

470.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Bach P, et al. Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283. J Med Chem. 2013 Sep 12;56 (17) :7015-24.|[2]Kong D, et al. Optimization of P2Y12 Antagonist Ethyl 6- (4- ((Benzylsulfonyl) carbamoyl) piperidin-1-yl) -5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties. J Med Chem. 2019 Mar 28;62 (6) :3088-3106.