Cucurbitacin E

Cucurbitacin E is a natural compound which from Cucurbitaceae plants. Cucurbitacin E significantly suppresses the activity of the cyclin B1/CDC2 complex.

Product Specifications

CAS Number

[18444-66-1]

Product Name Alternative

α-Elaterin; α-Elaterine

UNSPSC

12352211

Hazard Statement

H302

Target

Autophagy; CDK

Type

Natural Products

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Cucurbitacin-E.html

Purity

99.92

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O[C@H](C1)[C@@]([C@@](C)(O)C(/C=C/C(OC(C)=O)(C)C)=O)([H])[C@](C2)(C)[C@]1(C)[C@]3([H])CC=C4C(C)(C)C(C(O)=C[C@@]4([H])[C@]3(C)C2=O)=O

Molecular Formula

C32H44O8

Molecular Weight

556.69

Precautions

H302

References & Citations

[1]Hsu YC, et al. Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E. Cell Death Dis. 2014 Apr 24;5:e1198.|[2]Murtaza M, et al. Cucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway. PLoS One. 2017 Jun 9;12 (6) :e0178910.