Maytansinol

Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research[1][2].

Product Specifications

CAS Number

[57103-68-1]

Product Name Alternative

Ansamitocin P-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Apoptosis; Microtubule/Tubulin

Type

Natural Products

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Maytansinol.html

Purity

99.84

Solubility

DMSO : ≥ 35 mg/mL

Smiles

C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1

Molecular Formula

C28H37ClN2O8

Molecular Weight

565.06

Precautions

H302, H315, H319, H335

References & Citations

[1]Zafar S, et al. New insights into the anticancer therapeutic potential of maytansine and its derivatives. Biomed Pharmacother. 2023 Sep;165:115039.|[2]Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4 (4) :496-503.