HFI-437
HFI-437 is a potent non-peptidic insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 20 nM. HFI-437 is a cognitive enhancer[1].
Product Specifications
CAS Number
[1110650-74-2]
UNSPSC
12352005
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hfi-437.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(NC(C)=O)OC2=CC(O)=CC=C2C1C3=CN=C4C=CC=CC4=C3)OCC
Molecular Formula
C23H20N2O5
Molecular Weight
404.42
References & Citations
[1]Anthony L Albiston, et al. Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J. 2008 Dec;22 (12) :4209-17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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