PF 03716556

PF 03716556 is a potent, selective, competitive and reversible acid pump (H+, K+-ATPase) antagonist with pIC50s of 6.026, 6.038 and 6.009 for porcine, canine, and human recombinant gastric H+, K+-ATPase, respectively. PF 03716556 is inactive against other receptors, ion channels, and enzymes. PF 03716556 has the potential for gastroesophageal reflux disease research[1].

Product Specifications

CAS Number

[928774-43-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/PF-03716556.html

Purity

99.10

Solubility

DMSO : 23 mg/mL (ultrasonic; warming)

Smiles

CC1=CN2C=C(C=C(C2=N1)N[C@H]3C4=C(C=CC=C4OCC3)C)C(N(CCO)C)=O

Molecular Formula

C22H26N4O3

Molecular Weight

394.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Hiroki Mori, et al. N- (2-hydroxyethyl) -N,2-dimethyl-8-{[ (4R) -5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. J Pharmacol Exp Ther. 2009 Feb;328 (2) :671-9.