BBS-4

BBS-4 is a potent and selective inducible nitric oxide synthase (NOS2) dimerization inhibitor, with an IC50 of 0.49 nM. BBS-4 can protect mice from the cardiovascular dysfunction of sepsis[1].

Product Specifications

CAS Number

[402934-09-2]

UNSPSC

12352005

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bbs-4.html

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1N(C2=NC(N3C=CN=C3)=NC(C)=C2)CCC1)NCCC4=CC=C(OCO5)C5=C4

Molecular Formula

C22H24N6O3

Molecular Weight

420.46

References & Citations

[1]Ichinose F, et, al. A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Physiol Heart Circ Physiol. 2003 Dec; 285 (6) : H2524-30.|[2]https://pubmed.ncbi.nlm.nih.gov/12907425/