Rivaroxaban-d4

Rivaroxaban-d4 (BAY 59-7939-d4) is a deuterium labeled Rivaroxaban. Rivaroxaban is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM) [1][2].

Product Specifications

CAS Number

[1132681-38-9]

Product Name Alternative

BAY 59-7939-d4

UNSPSC

12352005

Hazard Statement

H302

Target

Factor Xa

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

98.73

Solubility

10 mM in DMSO|DMSO : 50mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(Cl)S1)NC[C@H]2CN(C3=C([2H])C([2H])=C(N4C(COCC4)=O)C([2H])=C3[2H])C(O2)=O

Molecular Formula

C19H14D4ClN3O5S

Molecular Weight

439.91

Precautions

H302

References & Citations

[1]Roehrig S, et al. Discovery of the novel antithrombotic agent 5-chloro-N- ({ (5S) -2-oxo-3- [4- (3-oxomorpholin-4-yl) phenyl]-1,3-oxazolidin-5-yl}methyl) thiophene- 2-carboxamide (BAY 59-7939) : an oral, direct factor Xa inhibitor. J Med Chem. 2005 Sep 22;48 (19) |[2]Perzborn E, et al. In vitro and in vivo studies of the novel antithrombotic agent BAY 59-7939--an oral, direct Factor Xa inhibitor. J Thromb Haemost. 2005 Mar;3 (3) :514-21.