SC99
Product Specifications
UNSPSC Description
SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kinases associated with STAT3 signaling. SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities[1][2][3].
Target Antigen
Apoptosis; JAK; STAT
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sc99.html
Purity
98.96
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
N#C/C(C(C1=CC=C(Cl)C=C1)=O)=N\NC2=CC=C(F)C(Cl)=C2
Molecular Weight
336.15
References & Citations
[1]Zubin Zhang, et al. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget. 2016 Feb 23;7(8):9296-308.|[2]Zhuan Xu, et at. A novel STAT3 inhibitor negatively modulates platelet activation and aggregation. Acta Pharmacol Sin. 2017 May;38(5):651-659.|[3]Yiping Ding, et al. Effects of SC99 on cerebral ischemia-perfusion injury in rats: Selective modulation of microglia polarization to M2 phenotype via inhibiting JAK2-STAT3 pathway. Neurosci Res. 2019 May;142:58-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124858/SC99-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124858/SC99-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
882290-02-0
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
R10609m EACH
Mouse Dpp6 / Dipeptidyl aminopeptidase-like protein 6 Recombinant Protein
Ask
View Details 
TRC-C315510-25MG 25 mg
7-Chloro-1-Ethyl-6-Fluoro-1,4-Dihydro-4-Oxo-3-Quinolinecarboxylic Acid Ethyl Ester
Ask
View Details 
MBS1431975-01 0.02 mg (E-Coli)
Recombinant Pseudoalteromonas haloplanktis ATP synthase epsilon chain (atpC)
Ask
View Details MBS1431975-02 0.1 mg (E-Coli)
Recombinant Pseudoalteromonas haloplanktis ATP synthase epsilon chain (atpC)
Ask
View Details