LDC4297

LDC4297 is a selective inhibitor of CDK7 with an IC50 value of 0.13 nM. LDC4297 inhibits human cytomegalovirus (HCMV) replication with an EC50 value of 24.5 nM. LDC4297 shows broad antiviral activities to Herpesviridae, Adenoviridae, Poxviridae, Retroviridae and Orthomyxoviridae with EC50 value of 0.02-1.21 μM. LDC4297 can be used for the research of infection[1].

Product Specifications

CAS Number

[1453834-21-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK; HIV; HSV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/LDC4297.html

Purity

98.14

Solubility

DMSO : ≥ 60 mg/mL

Smiles

CC(C)C1=C(N2N=C1)N=C(OC3CNCCC3)N=C2NCC4=CC=CC=C4N5C=CC=N5

Molecular Formula

C23H28N8O

Molecular Weight

432.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Hutterer C, et al. A novel CDK7 inhibitor of the Pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrations. Antimicrob Agents Chemother. 2015 Apr;59 (4) :2062-71.