Ilaprazole

Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor[1][2].

Product Specifications

CAS Number

[172152-36-2]

Product Name Alternative

IY-81149

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Proton Pump; TOPK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Ilaprazole.html

Purity

99.97

Solubility

DMSO : ≥ 35 mg/mL|Ethanol : 5 mg/mL (ultrasonic)

Smiles

O=S(C1=NC2=CC=C(N3C=CC=C3)C=C2N1)CC4=NC=CC(OC)=C4C

Molecular Formula

C19H18N4O2S

Molecular Weight

366.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Kwon D, et al. Effects of IY-81149, a newly developed proton pump inhibitor, on gastric acid secretion in vitro and in vivo. Arzneimittelforschung. 2001;51 (3) :204-13.|[2]Zheng M, et al. Proton pump inhibitor ilaprazole suppresses cancer growth by targeting T-cell-originated protein kinase. Oncotarget. 2017;8 (24) :39143-39153.