Selatogrel

Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy[1].

Product Specifications

CAS Number

[1159500-34-1]

Product Name Alternative

ACT-246475

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/selatogrel.html

Purity

99.75

Solubility

10 mM in DMSO

Smiles

O=C(N1CCN(CC1)C(OCCCC)=O)[C@H](CP(O)(O)=O)NC(C2=CC(N3C[C@H](CC3)OC)=NC(C4=CC=CC=C4)=N2)=O

Molecular Formula

C28H39N6O8P

Molecular Weight

618.62

References & Citations

[1]Caroff E, et al., 4- ((R) -2-{[6- ((S) -3-Methoxypyrrolidin-1-yl) -2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl) piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. J Med Chem. 2015 Dec 10;58 (23) :9133-53.