MK-0354
Product Specifications
UNSPSC Description
MK-0354 is a specific GPR109a receptor agonist, acting on hGPR109a/mGPR109a, with EC50 of 1.65 μM and 1.08 μM respectively, and has no effect on GPR109b.
Target Antigen
GPR109A
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/MK-0354.html
Purity
99.73
Solubility
DMSO : ≥ 36 mg/mL
Smiles
C12=C(CCC2)C(C3=NN=NN3)=NN1
Molecular Weight
176.18
References & Citations
[1]Semple G, et al. 3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice. J. Med. Chem., 2008, 51 (16), pp 5101-5108|[2]Lai E1, et al. Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans. J Clin Lipidol. 2008 Oct;2(5):375-383.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13008/MK-0354-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13008/MK-0354-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
851776-28-8
Available Sizes
Curated Selection
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