Drupanin

Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC50 value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers[1][2][3].

Product Specifications

CAS Number

[53755-58-1]

UNSPSC

12352005

Target

Aldose Reductase; PPAR; RAR/RXR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/drupanin.html

Purity

99.35

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C(C)=C\CC1=C(C=CC(/C=C/C(O)=O)=C1)O

Molecular Formula

C14H16O3

Molecular Weight

232.28

References & Citations

[1]Rodrigues DM, et al. Synthesis, antitumor activity and in silico analyses of amino acid derivatives of artepillin C, drupanin and baccharin from green propolis. Bioorg Med Chem. 2021;47:116372.|[2]Nakashima K, et al. Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis. Biochim Biophys Acta. 2014 Oct;1840 (10) :3034-41.|[3]Mishima S, et al. Two related cinnamic Acid derivatives from Brazilian honey bee propolis, baccharin and drupanin, induce growth inhibition in allografted sarcoma S-180 in mice. Biol Pharm Bull. 2005 Jun;28 (6) :1025-30.