MTR-106

MTR-106 is a potent and orally active G-quadruplex stabilizer and RNA polymerase I inhibitor. MTR-106 induces apoptosis and inhibits cell growth. MTR-106 can be used in research of cancer[1].

Product Specifications

CAS Number

[1639357-93-9]

UNSPSC

12352005

Target

Apoptosis; DNA/RNA Synthesis; G-quadruplex

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mtr-106.html

Purity

99.40

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CN=C(C=N1)CNC(C2=C3N(C4=CC=CC=C4S3)C5=NC(N6C[C@]7([H])[C@](CN(C7)C)([H])C6)=CC=C5C2=O)=O

Molecular Formula

C28H27N7O2S

Molecular Weight

525.62

References & Citations

[1]Li MZ, et, al. Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers. Invest New Drugs. 2021 Oct;39 (5) :1213-1221.