(±) -Vesamicol (hydrochloride)

(±) -Vesamicol hydrochloride ((±) -AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. (±) -Vesamicol hydrochloride also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively[1][2].

Product Specifications

CAS Number

[120447-62-3]

Product Name Alternative

(±) -AH5183 (hydrochloride)

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/racemic-vesamicol-hydrochloride.html

Purity

99.81

Solubility

DMSO : 14 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@H](N2CCC(C3=CC=CC=C3)CC2)CCCC1.[H]Cl

Molecular Formula

C17H26ClNO

Molecular Weight

295.85

References & Citations

[1]S M Efange, et al. N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J Med Chem. 1997 Nov 21;40 (24) :3905-14.|[2]H Kobayashi, et al. Effects of systemic administration of 2- (4-phenyl-piperidino) -cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain Res Bull. 1997;43 (1) :17-23.