L-Primapterin

L-Primapterin (7-Biopterin) is the 7-isomer of L-biopterin. L-Primapterin is a characteristic marker of hyperphenylalaninemia variant primapterinuria, which is excreted in the urine[1][2].

Product Specifications

CAS Number

[2636-52-4]

Product Name Alternative

7-Biopterin

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/l-primapterin.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=NC=C([C@@H](O)[C@@H](O)C)NC2=NC(N)=N1

Molecular Formula

C9H11N5O3

Molecular Weight

237.22

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Curtius HC, et al. Progress in the study of biosynthesis and role of 7-substituted pterins: function of pterin-4a-carbinolamine dehydratase. Adv Exp Med Biol. 1993;338:107-10. |[2]Ayling JE, et al. Hyperphenylalaninemia and 7-pterin excretion associated with mutations in 4a-hydroxy-tetrahydrobiopterin dehydratase/DCoH: analysis of enzyme activity in intestinal biopsies. Mol Genet Metab. 2000 Jul;70 (3) :179-88.