Squalamine

Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson, s disease mouse models[1][2][3][4][5].

Product Specifications

CAS Number

[148717-90-2]

Product Name Alternative

MSI-1256; ENT-01 (free acid)

UNSPSC

12352211

Target

Bacterial; Dengue Virus; FAK; HBV

Type

Natural Products

Related Pathways

Anti-infection; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Squalamine.html

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CC[C@H](C(C)C)OS(=O)(O)=O)C)([H])C[C@@H](NCCCNCCCCN)CC1

Molecular Formula

C34H65N3O5S

Molecular Weight

627.96

References & Citations

[4]West CL, et al. Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease. J Parkinsons Dis. 2020;10 (4) :1477-1491.|[5]Moore KS, et al. Squalamine: an aminosterol antibiotic from the shark. Proc Natl Acad Sci U S A. 1993 Feb 15;90 (4) :1354-8.|[1]Zasloff M, et al. Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential. Proc Natl Acad Sci U S A. 2011 Sep 20;108 (38) :15978-83.|[2]Djouhri-Bouktab L, et al. Squalamine ointment for Staphylococcus aureus skin decolonization in a mouse model. J Antimicrob Chemother. 2011 Jun;66 (6) :1306-10.|[3]Márquez-Garbán DC, et al. Squalamine blocks tumor-associated angiogenesis and growth of human breast cancer cells with or without HER-2/neu overexpression. Cancer Lett. 2019 May 1;449:66-75.