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RU.521

Product Specifications

Product Name Alternative

Hydroxypropyl Cellulose, Viscosity(1%):4000-6500mPa.s,Hydroxypropyl Cellulose, Viscosity(1%):150-400mPa.s

UNSPSC Description

RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1].

Target Antigen

Cyclic GMP-AMP Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ru-521.html

Purity

99.95

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5

Molecular Weight

415.23

References & Citations

[1]Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.|[2]Xu Q, et al. Small molecule inhibition of cyclic GMP-AMP synthase ameliorates sepsis-induced cardiac dysfunction in mice. Life Sci. 2020 Nov 1;260:118315.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-114180/RU-521-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-114180/RU-521-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2262452-06-0

Available Sizes

Curated Selection

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