Lactate (sodium)

Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis[1]. Lactate (Lactic acid) sodium is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection[2][3][4][5]. Lactate sodium also has antimicrobial activity, which can be used as a food preservative[6].

[1]Brooks GA. Lactate: link between glycolytic and oxidative metabolism. Sports Med. 2007;37(4-5):341-3.|[2]Ichai C, et al. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Med. 2009 Mar;35(3):471-9. |[3]Rice AC, et al. Lactate administration attenuates cognitive deficits following traumatic brain injury. Brain Res. 2002 Feb 22;928(1-2):156-9. |[4]Hospira, Inc. (November 2004). "Sodium Lactate (sodium lactate) Injection, Solution, Concentrate". DailyMed. U.S. National Library of Medicine. Archived from the original on 2014-01-04. Retrieved 2012-08-16. |[5]Forsythe SM, et al. Sodium bicarbonate for the treatment of lactic acidosis. Chest. 2000 Jan;117(1):260-7. |[6]Sallam KI. Antimicrobial and antioxidant effects of sodium acetate, sodium lactate, and sodium citrate in refrigerated sliced salmon. Food Control. 2007 May;18(5):566-575. Cell Res. 2023 Jul 13.|J Anim Sci Biotechnol. 2024 Jun 11;15(1):86.|J Exp Clin Cancer Res. 2024 Mar 5;43(1):68.|Adv Sci (Weinh). 2024 May 20:e2307216.|Bioact Mater. 2024 Jun 24:40:445-459.|Cancer Immunol Immunother. 2024 Oct 3;73(12):254.|J Ginseng Res. 2023 Dec 27.|Tissue Cell. 2024 Jul 9:89:102468.