Ethinylestradiol

Ethinylestradiol is an orally active steroidal estrogen. Ethinylestradiol is widely used in research on menopausal symptoms, gynecological conditions, and certain hormone-sensitive cancers[1].

Product Specifications

CAS Number

[57-63-6]

Product Name Alternative

Ethynyl estradiol; 17α-Ethynylestradiol

UNSPSC

12352005

Hazard Statement

H302, H350

Target

Endogenous Metabolite; Estrogen Receptor/ERR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/ethinylestradiol.html

Purity

99.96

Solubility

DMSO : ≥ 100 mg/mL|Ethanol : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

OC1=CC=C2C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(C#C)O)=C1

Molecular Formula

C20H24O2

Molecular Weight

296.40

Precautions

H302, H350

References & Citations

[1]Arnal J F, et al. Ethinylestradiol does not enhance the expression of nitric oxide synthase in bovine endothelial cells but increases the release of bioactive nitric oxide by inhibiting superoxide anion production[J]. Proceedings of the National Academy of Sciences, 1996, 93 (9) : 4108-4113. |[2]Notch EG, et al. 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95 (4) :273-8.|[3]Bertolotti M, et al. Effect of hypocholesterolemic doses of 17 alpha-ethinyl estradiol on cholesterol balance in liver and extrahepatic tissues. J Lipid Res. 1996 Aug;37 (8) :1812-22. |[4]Mandrup KR, et al. Effects of perinatal ethinyl estradiol exposure in male and female Wistar rats. Reprod Toxicol. 2013 Dec;42:180-91. |[5]Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration. Climacteric. 2005 Aug;8 Suppl 1:3-63.