VU0364770
VU0364770 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively[1].
Product Specifications
CAS Number
[61350-00-3]
UNSPSC
12352005
Hazard Statement
H317, H319, H410
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/VU0364770.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C1=NC=CC=C1)NC2=CC=CC(Cl)=C2
Molecular Formula
C12H9ClN2O
Molecular Weight
232.67
Precautions
H317, H319, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4; mGluR5; mGluR6
Available Sizes
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