Lavendustin C

Lavendustin C is a potent Ca2+ calmodulin-dependent kinase II (CaMK II) inhibitor with an IC50 of 0.2 μM. Lavendustin C inhibits EGFR-associated tyrosine kinase (IC50=0.012 μM) and pp60c-src (+) kinase (IC50=0.5 μM) [1][2].

Product Specifications

CAS Number

[125697-93-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CaMK; EGFR; Src

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lavendustin-c.html

Purity

98.32

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(NCC2=CC(O)=CC=C2O)=CC=C1O

Molecular Formula

C14H13NO5

Molecular Weight

275.26

Precautions

H302, H315, H319, H335

References & Citations

[1]T Onoda, et al.Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, From Streptomyces Griseolavendus. J Nat Prod. Nov-Dec 1989;52 (6) :1252-7.|[2]T J O'Dell, et al.Long-term Potentiation in the Hippocampus Is Blocked by Tyrosine Kinase Inhibitors. Nature. 1991 Oct 10;353 (6344) :558-60.|[3]H M Burt, et al. Inhibition of Crystal-Induced Neutrophil Activation by a Protein Tyrosine Kinase Inhibitor. J Leukoc Biol. 1994 Jan;55 (1) :112-9.