High HAMA Serum

<strong>High HAMA Serum</strong>_x000D_ <table width="643">_x000D_ <tbody>_x000D_ <tr>_x000D_ <td>Catalog number:</td>_x000D_ <td>S2010006</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Lot number:</td>_x000D_ <td>Batch Dependent</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Expiration date:</td>_x000D_ <td>Batch Dependent</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Volume:</td>_x000D_ <td>1 mL</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Appearance:</td>_x000D_ <td>Yellow orange</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Matrix:</td>_x000D_ <td>Human serum</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Storage:</td>_x000D_ <td>At -20°C or lower. Avoid repeated freeze-thaw cycles. Aliquot as needed.</td>_x000D_ </tr>_x000D_ <tr>_x000D_ <td>Keywords</td>_x000D_ <td>HAMA sample, Human Anti-Mouse Antibodies serum, High HAMA plasma</td>_x000D_ </tr>_x000D_ </tbody>_x000D_ </table>_x000D_ &nbsp;_x000D_ _x000D_ <strong>About HAMA</strong>_x000D_ _x000D_ Immunoassays rely heavily on mouse antibodies for the detection of various analytes. The accuracy of these assays can, however, suffer when samples contain human anti-mouse antibodies (HAMA). Indeed, HAMA are often associated with inaccurate results because they can bind to both capture and detection antibodies and can generate non-specific signals. This so-called HAMA effect is major interference issue. Assessing the tolerance of an immunoassay to HAMA and mitigating it is very important important during research and development._x000D_ _x000D_ <strong>References</strong>_x000D_ <ul>_x000D_ <li>Reinsberg J. (1996). Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay. <em><span role="menubar">Clin Biochem.</span></em> 1996 Apr;29(2):145-8.</li>_x000D_ <li>Bolstad N, Warren DJ, Nustad K. Heterophilic antibody interference in immunometric assays. <em><span class="jrnl" title="Best practice &amp; research. Clinical endocrinology &amp; metabolism">Best Pract Res Clin Endocrinol Metab</span></em>. 2013 Oct;27(5):647-61.</li>_x000D_ <li>Lippi G, Aloe R, Meschi T, Borghi L, Cervellin G. Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature. <em><span class="jrnl" title="Clinica chimica acta; international journal of clinical chemistry">Clin Chim Acta</span></em>. 2013 Nov 15;426:79-84.</li>_x000D_ <li>Kawasaki H, Suzuki T, Ito K, Takahara T, Goto-Inoue N, Setou M, Sakata K, Ishida N. Minos-insertion mutant of the Drosophila GBA gene homologue showed abnormal phenotypes of climbing ability, sleep and life span with accumulation of hydroxy-glucocerebroside. <span class="jrnl" title="Gene">Gene</span>. 2017 May 30;614:49-55.</li>_x000D_ <li>Hull B. Aberrantly elevated TSH level due to human anti-mouse antibodies (HAMA) interference with thyrotropin assay. <a href="https://www.ncbi.nlm.nih.gov/pubmed/23270080"><span class="jrnl" title="Journal of the South Carolina Medical Association (1975)">J S C Med Assoc</span>.</a> 2012 Feb;108(1):12-3.</li>_x000D_ <li>Degn SE, Andersen SH, Jensen L, Thiel S, Jensenius JC. Assay interference caused by antibodies reacting with rat kappa light-chain in human sera. <span class="jrnl" title="Journal of immunological methods">J Immunol Methods</span>. 2011 Sep 30;372(1-2):204-8.</li>_x000D_ </ul>_x000D_ <strong>Products Related to HAMA High Serum_x000D_ </strong>_x000D_ _x000D_ https://moleculardepot.com/product/hama-interference-kit-for-assay-validation/_x000D_ _x000D_ https://moleculardepot.com/product/hama-blocking-reagent-10-mg/