Mezigdomide
Mezigdomide (CC-92480), a cereblon E3 ubiquitin ligase modulating agent (CELMoD), acts as a molecular glue. Mezigdomide shows high affinity to cereblon, resulting in potent antimyeloma activity[1].
Product Specifications
CAS Number
[2259648-80-9]
Product Name Alternative
CC-92480
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H361
Target
Apoptosis; E1/E2/E3 Enzyme; Molecular Glues
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cc-92480.html
Purity
99.16
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC=C(N2CCN(CC3=CC=C(COC4=CC=CC5=C4CN([C@@H](CC6)C(NC6=O)=O)C5=O)C=C3)CC2)C(F)=C1
Molecular Formula
C32H30FN5O4
Molecular Weight
567.61
Precautions
H302, H315, H319, H335, H361
References & Citations
[1]Nooka AK, et al. Mechanism of Action and Novel IMiD-Based Compounds and Combinations in Multiple Myeloma. Cancer J. 2019 Jan/Feb;25 (1) :19-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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