DC0-NH2

DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin) . DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component[1].

Product Specifications

CAS Number

[615538-51-7]

UNSPSC

12352203

Target

ADC Payload

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dc0-nh2.html

Purity

95.00

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(N1)=CC2=C1C=CC(N)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3

Molecular Formula

C31H24ClN5O3

Molecular Weight

550.01

References & Citations

[1]Zhao RY, et al. Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer.J Med Chem. 2012 Jan 26;55 (2) :766-82.