Sitostanol

Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and IL-10. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma[1][2][3][4].

Product Specifications

CAS Number

[83-45-4]

Product Name Alternative

Stigmastanol; 24α-Ethyl cholestanol

UNSPSC

12352211

Hazard Statement

H301+H311+H331

Target

Interleukin Related

Type

Natural Products

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Others

Assay Protocol

https://www.medchemexpress.com/Stigmastanol.html

Purity

99.0

Solubility

DMSO : < 1 mg/mL|Ethanol : 5 mg/mL (ultrasonic)

Smiles

CC[C@H](CC[C@@H](C)[C@]1([H])[C@]2(C)[C@](CC1)([H])[C@]3([H])CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC2)C(C)C

Molecular Formula

C29H52O

Molecular Weight

416.72

Precautions

H301+H311+H331

References & Citations

[1]Pinhas H, et al. 6-amino derivatives of stigmastanol and cholestanol. J Med Chem. 1971;14 (11) :1048-1049.|[2]Tanemossu SA, et al. Rare biscoumarin derivatives and flavonoids from Hypericum riparium. Phytochemistry. 2014;105:171-177.|[3]Nascimento EBM, et al. In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes. Eur J Nutr. 2020 Aug;59 (5) :2039-2045.|[4]Brüll F, et al. Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach. PLoS One. 2012;7 (10) :e46895.