Bimoclomol

Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases.

Product Specifications

CAS Number

[130493-03-7]

UNSPSC

12352005

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Bimoclomol.html

Purity

99.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

Cl/C(C1=CC=CN=C1)=N\OCC(O)CN2CCCCC2

Molecular Formula

C14H20ClN3O2

Molecular Weight

297.78

References & Citations

[1]Jednakovits A, et al. In vivo and in vitro acute cardiovascular effects of bimoclomol. Gen Pharmacol. 2000 May;34 (5) :363-9.|[2]Hargitai J, et al. Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1. Biochem Biophys Res Commun. 2003 Aug 1;307 (3) :689-95.|[3]Polakowski JS, et al. Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Eur J Pharmacol. 2002 Jan 18;435 (1) :73-7.