TWEAK/TNFSF12, Human/Cynomolgus (HEK293, Fc)

TWEAK Protein refers to the cytokine tumor necrosis factor-like weak inducer of apoptosis, belongs to tumor necrosis factor (TNF) superfamily. TWEAK protein binds to FN14 and TNRFSF12/APO3, is a weak inducer of apoptosis[1]. TWEAK does have pro-apoptotic activity for tumor cell, mediates NF-kappa-B activation, promotes angiogenesis and the proliferation of endothelial cells (ECs)[2]. TWEAK also increases IL-6 and IL-8 secretion, and could potentiate the pro-inflammatory activities of TNF and IL-1[3]. Human TWEAK protein is a type II transmembrane protein (M1-H249) with a transmembrane domain (22-42 a.a.). TWEAK/TNFSF12 Protein, Human/Cynomolgus (HEK293, Fc) is the extracellular part (S97-H249) of TWEAK protein, produced by HEK293 cells with N-terminal mFc-tag.

SAPKGRKTRA RRAIAAHYEV HPRPGQDGAQ AGVDGTVSGW EEARINSSSP LRYNRQIGEF IVTRAGLYYL YCQVHFDEGK AVYLKLDLLV DGVLALRCLE EFSATAASSL GPQLRLCQVS GLLALRPGSS LRIRTLPWAH LKAAPFLTYF GLFQVH

[1]Wiley SR, et al. TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):241-9.|[2]Lammens A, et al. Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding. PLoS One. 2013 May 8;8(5):e62697.|[3]Lynch CN, et al. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999 Mar 26;274(13):8455-9.|[4]Lynch CN, et al. TWEAK induces angiogenesis and proliferation of endothelial cells. J Biol Chem. 1999 Mar 26;274(13):8455-9.