Eriocitrin

Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria[1][1][2].

Product Specifications

CAS Number

[13463-28-0]

Product Name Alternative

Eriodictyol 7-rutinoside; Eriodictyol 7-O-rutinoside

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/eriocitrin.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic) |Methanol : 31.25 mg/mL (ultrasonic)

Smiles

O=C(C[C@@H](C1=CC(O)=C(O)C=C1)OC2=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO[C@H](O[C@@H](C)[C@H](O)[C@H]4O)[C@@H]4O)=C5)C2=C5O

Molecular Formula

C27H32O15

Molecular Weight

596.53

Precautions

H315, H319, H335

References & Citations

[1]Wang Z, et al. Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle. Cancer Chemother Pharmacol. 2016 Dec;78 (6) :1143-1150.|[2]Xu J, et al. Eriocitrin attenuates ischemia reperfusion-induced oxidative stress and inflammation in rats with acute kidney injury by regulating the dual-specificity phosphatase 14 (DUSP14) -mediated Nrf2 and nuclear factor-κB (NF-κB) pathways. Ann Transl Med. 2021 Feb;9 (4) :350.