BT18
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF) [1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].
Product Specifications
CAS Number
[924811-53-0]
UNSPSC
12352005
Target
GDNF Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bt18.html
Concentration
10mM
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C2=CC(S(=O)(N3CC4=C(C=C(OC)C(OC)=C4)CC3)=O)=CC=C2OC)CC1)C5=CC=C(F)C=C5C(F)(F)F
Molecular Formula
C30H31F4N3O6S
Molecular Weight
637.64
References & Citations
[1]Leo Jakman, Characterization of small-molecule GDNF mimics.|[2]Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3 (9) :11407-11414.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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