Glaucocalyxin B

Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC50 of approximately 5.86 μM at 24 h.

Product Specifications

CAS Number

[80508-81-2]

UNSPSC

12352211

Target

Autophagy

Type

Natural Products

Related Pathways

Autophagy

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Glaucocalyxin-B.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1(C)C(CC[C@@]2(C)[C@@]3([H])[C@@]4(C(C([C@H](CC3)[C@H]4OC(C)=O)=C)=O)[C@H](O)C[C@]12[H])=O

Molecular Formula

C22H30O5

Molecular Weight

374.47

References & Citations

[1]Yang WH, et al. Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells. Anticancer Agents Med Chem. 2013 Oct;13 (8) :1280-90.|[2]Pan Y, et al. Glaucocalyxin B induces apoptosis and autophagy in human cervical cancer cells. Mol Med Rep. 2016 Aug;14 (2) :1751-5.|[3]Gan P, et al. Anti-inflammatory effects of glaucocalyxin B in microglia cells. J Pharmacol Sci. 2015 May;128 (1) :35-46.