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Arazine

Arazine (N-Acetyl-S-farnesyl-L-cysteine) is a cell-permeable modulator of G protein and G-protein coupled receptor signaling. Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site[1].

Product Specifications

CAS Number

[135304-07-3]

Product Name Alternative

N-Acetyl-S-farnesyl-L-cysteine

UNSPSC

12352211

Hazard Statement

H225-H319-H336

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/arazine.html

Concentration

27.2 mM * 500 μL in Methyl acetate

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@H](CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)NC(C)=O

Molecular Formula

C20H33NO3S

Molecular Weight

367.55

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Gordon JS, et al. Topical N-acetyl-S-farnesyl-L-cysteine inhibits mouse skin inflammation, and unlike dexamethasone, its effects are restricted to the application site.J Invest Dermatol. 2008 Mar;128 (3) :643-54. Epub 2007 Sep 20.|[2]Adhami K, et al. N-acetyl-S-farnesyl-l-cysteine suppresses chemokine production by human dermal microvascular endothelial cells.Exp Dermatol. 2012 Sep;21 (9) :700-5.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-133021/Arazine-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-133021/Arazine-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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