L-701324

L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC50=2 nM) . L-701324 has antidepressant activity[1][2][3].

Product Specifications

CAS Number

[142326-59-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/L-701324.html

Purity

99.85

Solubility

DMSO : ≥ 34 mg/mL

Smiles

O=C1NC2=C(C=CC(Cl)=C2)C(O)=C1C3=CC=CC(OC4=CC=CC=C4)=C3

Molecular Formula

C21H14ClNO3

Molecular Weight

363.79

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu L, et, al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behav Brain Res. 2021 Feb 5;399:113038.|[2]Kotlinska J, et, al. A characterization of anxiolytic-like actions induced by the novel NMDA/glycine site antagonist, L-701,324. Psychopharmacology (Berl) . 1998 Jan;135 (2) :175-81.|[3]Hutson PH, et, al. L-701,324, a glycine/NMDA receptor antagonist, blocks the increase of cortical dopamine metabolism by stress and DMCM. Eur J Pharmacol. 1997 May 20;326 (2-3) :127-32.