9-Methoxycanthin-6-one

9-Methoxycanthin-6-one, a canthin-6-one alkaloid, is present in intact plant parts and in callus tissues of different explants. 9-Methoxycanthin-6-one shows anti-tumor activity, inhibits LPS-induced TNF-α and IL-1β[1][2][3].

Product Specifications

CAS Number

[74991-91-6]

UNSPSC

12352005

Target

Phosphodiesterase (PDE) ; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/9-methoxycanthin-6-one.html

Concentration

10mM

Purity

99.80

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C1N2C3=C(N=CC=C3C4=C2C=C(OC)C=C4)C=C1

Molecular Formula

C15H10N2O2

Molecular Weight

250.25

References & Citations

[1]Maziah M, et al. The Production of 9-methoxycanthin-6-one from Callus Cultures of (Eurycoma longifolia Jack) Tongkat Ali. Methods Mol Biol. 2009;547:359-69.|[2]Tripetch Kanchanapoom , et al. Canthin-6-one and b-carboline alkaloids from Eurycoma harmandiana. Phytochemistry 56 (2001) 383-386.|[3]Zhang Z, et al. Canthin-6-Ones: Potential Drugs for Chronic Inflammatory Diseases by Targeting Multiple Inflammatory Mediators. Molecules. 2023 Apr 11;28 (8) :3381.