3-Hydroxycoumarin

3-hydroxycoumarin is a potent and redox inhibitor of human 15-LOX-1. 3-hydroxycoumarin is recently demonstrated to protect sea urchin reproductive cells against ultraviolet B damage[1][2].

Product Specifications

CAS Number

[939-19-5]

UNSPSC

12352005

Hazard Statement

H302

Target

Lipoxygenase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/3-hydroxycoumarin.html

Purity

99.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(O)=CC2=CC=CC=C2O1

Molecular Formula

C9H6O3

Molecular Weight

162.14

Precautions

H302

References & Citations

[1]Born SL, et al. Synthesis and reactivity of coumarin 3,4-epoxide. Drug Metab Dispos. 1997;25 (11) :1318‐1324.|[2]Alavi SJ, Sadeghian H, Seyedi SM, Salimi A, Eshghi H. A novel class of human 15-LOX-1 inhibitors based on 3-hydroxycoumarin. Chem Biol Drug Des. 2018;91 (6) :1125‐1132.|[3]Asthana S, et al. Structure-Activity Relationship Study of Hydroxycoumarins and Mushroom Tyrosinase. J Agric Food Chem. 2015;63 (32) :7236‐7244.