UP163
Product Specifications
UNSPSC Description
UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC50 of 9.0 μM. UP163 reduces MG-132 (HY-13259)-induced TDP-43 aggregates[1].
Target Antigen
p97
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/up163.html
Smiles
O=C(C1=CC=CO1)OCCN(C2=NS(=O)(C3=C2C=CC=C3)=O)C4=CC=C(C=C4)Cl
Molecular Weight
430.86
References & Citations
[1]Phan JM, et al., VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models. J Clin Invest. 2024 May 23;134(14):e169039.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168323/UP163-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168323/
Clinical Information
No Development Reported
CAS Number
591242-60-3
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