DB0614

DB0614 is a PROTAC based on Cereblon ligand, which is a selective and potent targeted protein degrader of NEK9 inhibitor. DB0614 can degrade ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2 and ULK1. DB0614 can be used for research of disease or disorder mediated by aberrant kinase activity[1][2]. (Blue: Thalidomide-4-OH (HY-103596), Black: linker, Pink: FLT3-IN-17 (HY-148070) )

Product Specifications

CAS Number

[2769753-47-9]

UNSPSC

12352005

Target

AAK1; Aurora Kinase; CaMK; CDK; Ferroptosis; LIM Kinase (LIMK) ; PROTACs; Salt-inducible Kinase (SIK) ; ULK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Neuronal Signaling; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/db0614.html

Purity

98.80

Solubility

DMSO : 2.78 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)

Smiles

O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(OCCCCCN4CCN(CC4)C5=CC=C(NC6=NC7=C(SC=C7C8=CC(NS(=O)(C)=O)=CC=C8)C=N6)C=C5)=CC=C2

Molecular Formula

C41H42N8O7S2

Molecular Weight

822.95

References & Citations

[1]SeongShick Ryu, et al. Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9[J]. Current Research in Chemical Biology. 2021. 1:100008.|[2]William Thomas Darlow, et al. Discovery of NEK9 and Aurora A PROTACs Using a Proteomics-Based Screening Approach. The Institute of Cancer Research. 2022. |[3]GRAY, Nathanael S. Compounds for targeted protein degradation of kinases. WO2022093742. 2022/093742