Thienopyridone

Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects[1].

Product Specifications

CAS Number

[1018454-97-1]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Phosphatase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thienopyridone.html

Purity

95.14

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 80°C)

Smiles

O=C1C(C=C(C2=CC=CC=C2)S3)=C3C(N)=CN1

Molecular Formula

C13H10N2OS

Molecular Weight

242.30

Precautions

H302

References & Citations

[1]Daouti S, et al. A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. Cancer Res. 2008 Feb 15;68 (4) :1162-9.