Thienopyridone
Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects[1].
Product Specifications
CAS Number
[1018454-97-1]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thienopyridone.html
Purity
95.14
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 80°C)
Smiles
O=C1C(C=C(C2=CC=CC=C2)S3)=C3C(N)=CN1
Molecular Formula
C13H10N2OS
Molecular Weight
242.30
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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CCR4-NOT transcription complex subunit 4 (CNOT4, CCR4-associated factor 4, CLONE243, E3 ubiquitin protein ligase CNOT4, NOT4, NOT4H, Potential transcriptional repressor NOT4Hp)