Thienopyridone
Product Specifications
UNSPSC Description
Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects[1].
Target Antigen
Apoptosis; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thienopyridone.html
Purity
98.05
Solubility
DMSO : 5 mg/mL (ultrasonic;warming;adjust pH to 5 with HCl;heat to 80°C)
Smiles
O=C1C(C=C(C2=CC=CC=C2)S3)=C3C(N)=CN1
Molecular Weight
242.30
References & Citations
[1]Daouti S, et al. A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. Cancer Res. 2008 Feb 15;68(4):1162-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-128153/Thienopyridone-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-128153/Thienopyridone-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1018454-97-1
Available Sizes
Curated Selection
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